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Ewelina M. Bartoszek on Muck Rack

Ewelina M. Bartoszek

As seen in: Nature
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Articles

Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker - Nature Communications

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By Tomas Martins, Deniz Kaymak, Nazanin Tatari, Sabrina Hogan, Marie-Françoise Ritz, Ewelina M. Bartoszek, Alicia Buck, Anja Heider, Jean-Louis Boulay, Yasuyuki Saito, Berend Snijder, Tobias Weiss, Heinz Läubli, Fiona Gerster, Aisha Beshirova
| Nature Verified
Abstract A significant challenge for chimeric antigen receptor (CAR) T cell therapy against glioblastoma (GBM) is its immunosuppressive microenvironment, which is densely populated by protumoral glioma-associated microglia and macrophages (GAMs). Myeloid immune checkpoint therapy targeting the CD47-signal regulatory protein alpha (SIRPα) axis induces GAM phagocytic function, but CD47 blockade monotherapy is associated with toxicity and low bioavailability in solid tumors.
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Mitochondrial-derived peptides, HNG and SHLP3, protect cochlear hair cells against gentamicin - Cell Death Discovery

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By Ewelina M. Bartoszek, Maurizio Cortada
| Nature Verified
Abstract Preservation of hair cells is critical for maintaining hearing function, as damage to sensory cells potentially leads to irreparable sensorineural hearing loss. Hair cell loss is often associated with inflammation and oxidative stress. One promising class of bioactive peptides is mitochondrial-derived peptides (MDPs), which have already been proven to protect various tissues from cellular stresses and delay aging processes.
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