Skip To Main Content
Euan Rodger on Muck Rack

Euan Rodger

As seen in: Nature, Cell Press, Great British LIFE, Future Medicine, Cornwall Life, TechTrends

Get in touch with Euan

Contact Euan, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Articles

Written in blood: DNA methylation in liquid biopsy

|
By Aniruddha Chatterjee, Euan Rodger
| Nature Verified
Circulating cell-free DNA (cfDNA) encodes a wealth of biological information, reflecting both tissue-of-origin signals and the underlying cellular states from which it is released. Advances in genome-wide profiling have enabled the deep interrogation of this hidden information, catalysing rapid progress in liquid biopsy for cancer detection and monitoring.
Open in Who Shared Issue with article?

Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy

|
By Abdullah Al Emran, Aniruddha Chatterjee, Euan Rodger
| Cell Press Verified
Highlights Genome-wide DNA methylation is a relatively stable epigenetic characteristic of cells, which can be dysregulated in cancer cells by oncogenic signals. Hyper- or hypomethylation of DNA in melanoma cells underlies the categorization of melanoma patients into four groups according to PD-L1 expression and T cell infiltration.
Open in Who Shared Issue with article?

Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

|
By Aniruddha Chatterjee, Euan Rodger, Antonio Ahn
| Cell Press Verified
To compare the RRBS methylation profiles observed in PD-L1and PD-L1cell lines with that of melanoma tumors, we analyzed 450K DNA methylation data from the TCGA-SKCM cohort. We specifically analyzed tumors that were TIL− to reduce the impact of immune cell signaling on tumor PD-L1 expression, and we divided these tumors into group 1 (PD-L1−, n = 180) and group 2 (PD-L1+, n = 54).
Open in Who Shared Issue with article?
See all 4 licensed articles (10 Total)