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Eve Byington

As seen in: Cell Reports
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Articles

Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex

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By Maya M.L. Poon, Wenzhao Meng, Eve Byington, Masaru Kubota
| Cell Reports Verified
Highlights • CD8+ T cells specific for influenza and CMV localize in multiple tissue sites • Persistence of memory CD8+ T cell subsets is shaped by virus tropism and specificity • Regulation of functional responses to viral antigens is primarily tissue mediated • Age and sex influence T cell subset differentiation and tissue residency Summary The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals.
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