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Evgeniy V. Petrotchenko on Muck Rack

Evgeniy V. Petrotchenko

As seen in: MDPI, Science Magazine, BioRxiv, Cell Press
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Articles

A Hit Prioritization Strategy for Compound Library Screening Using LiP-MS and Molecular Dynamics Simulations Applied to KRas G12D Inhibitors

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By Brandon Novy, Edith Nagy, Evgeniy V. Petrotchenko, Foroughsadat Absar
| BioRxiv
Abstract An important step in screening small molecule libraries for drug discovery is hit prioritization and validation to rule out false positives, which is usually performed using biochemical and biophysical assays. The development of orthogonal assays that are highly sensitive and can accelerate the hit-to-lead process is valuable. Limited proteolysis combined with mass spectrometry (LiP-MS) is a technique used to study changes in protein structure upon ligand binding.
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Characterization of the KRas G12D-inhibitor interactions by HDX-MS and molecular dynamics simulations

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By Evgeniy V. Petrotchenko, Brandon Novy, Edith Nagy, Konstantin Popov
| BioRxiv
Abstract Hydrogen-deuterium exchange (HDX) combined with mass spectrometry (MS) is a powerful technique for studying changes in protein structure and dynamics upon ligand binding. Protein-ligand complexes can result in increased protection of peptide-bond amides in HDX indicating protein structure stabilization.
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Multiplexed Dilute-and-Shoot Liquid Chromatography-Multiple-Reaction Monitoring Mass Spectrometry Clinical Assay for Metanephrines and Catecholamines in Human Urine

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By Deema O. Qasrawi, Evgeniy V. Petrotchenko, Christoph H Borchers, Shaun Eintracht
| MDPI
2. Materials and Methods 2.1. Materials Certified reference standards (catecholamine mix 1 (epinephrines), catecholamine mix 2 (metanephrines), dopamine, and 3-methoxytyramine) and certified deuterated internal standards (epinephrine-d6, norepinephrine-d6, dopamine-d4, metanephrine-d3, normetanephrine-d3, and 3-methoxytyramine-d4) were purchased from Cerilliant Corporation (Round Rock, TX, USA). LC-MS-grade ACN, water, and formic acid were purchased from Sigma-Aldrich (St. Louis, MO, USA).
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