Darren Darren

Bang, bang! Bang, bang, bang! Bang, bang, bang, bang! ARSENAL!!! What a racket we made as the teacher (a well known Magistrate) tried in vain to control his maths class first thing on a Monday morning. A strict, no-nonsense disciplinarian. He was powerless. He could not silence us. The school had not been infiltrated over the weekend by twenty-odd young Gooners. The ear-splinting noise was coming from Evertonians. Charlie George had smashed home a Cup final winner that weekend.

I was born too late to have seen "The Busby Babes". I was aware of them, of course. Some of my earliest football memories are of older family members telling me about the Munich plane crash; the great team Busby was building; Duncan Edwards. Manchester United had an aura about them back then. The hatred of all things Mancunian had yet to manifest itself here in Liverpool. Sure, there was a fierce rivalry between the two cities, but it was healthy and good.

Abstract The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural investigation of CRBN has been limited by current constructs that either require co-expression with the adaptor DDB1 or inadequately represent full-length protein, with high-resolution structures of degrader ternary complexes remaining rare.