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Ewan R Pearson on Muck Rack

Ewan R Pearson

As seen in: Color Research & Application, Nature, Wiley Online Library, The Lancet, Diabetes Care Magazine, The Journal of Clinical Investigation, Future Medicine, Inkl
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Articles

Five tenets for advancing evidence-based precision medicine

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By Daniel E. Coral, Jennifer Sargent, Julia Carrasco-Zanini, Luis Coral, Aaron Deutsch, Miriam S. Udler, Giuseppe Giordano, Guillaume Pare, Ewan R Pearson, Maarten van Smeden, Paul W. Franks
| Nature Verified
Abstract Precision medicine for complex diseases uses individual-level characteristics to improve prediction of risk, therapeutic response and prognosis. Many precision medicine studies leverage existing data types and analytic methods to reveal new insights; however, beyond oncology, there has been limited success in translating precision medicine research for complex diseases into clinical practice.
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GLP-1RA precision medicine in people with type 2 diabetes: current insights and future prospects

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By Pedro Cardoso, John Dennis, Ewan R Pearson
| The Journal of Clinical Investigation
Heterogeneity of treatment effects for GLP-1RAs As with all interventions, individual responses to GLP-1RAs vary. Most individuals initiating a GLP-1RA will experience both HbA1c and weight benefits; however, some will achieve weight loss but minimal improvement in glycemic control, while others have a large reduction in HbA1c with minimal or no weight loss (Figure 1).
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Precision phenotyping of type 2 diabetes in chinese populations using a variational autoencoder-informed tree model - Nature Communications

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By Yu Ding, Mengchun Gong, Ewan R Pearson, Sihui Luo
| Nature Verified
Abstract Type 2 diabetes (T2D) exhibits clinical heterogeneity, yet most existing classification models are derived from European populations and face challenges in clinical application. Here, we evaluate the generalizability of a tree-like graph structure from Scottish data to 32,501 newly diagnosed T2D patients from a multi-center Chinese cohort comprising over 8.6 million individuals.
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