EWOS Innovation

Highlights • Food intake is regulated primarily by dietary protein and carbohydrate • Low-protein, high-carbohydrate diets are associated with the longest lifespans • Energy reduction from high-protein diets or dietary dilution does not extend life • Diet influences hepatic mTOR via branched-chain amino acids and glucose Summary The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered.