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F. Romana Auciello on Muck Rack

F. Romana Auciello

As seen in: Cell Press
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Articles

Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

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By Fiona Ross, Simon A. Hawley, Graeme J. Gowans, F. Romana Auciello
| Cell Press Verified
AMPK Activation Does Not Require Src Kinases or LKB1 Tyrosine Phosphorylation SU6656 Does Not Activate AMPK by Binding at the ADaM Site SU6656 and AMP Promote Thr172 Phosphorylation by Binding to the Catalytic Site: Studies in Cell-Free Systems SU6656 and AMP Promote Thr172 Phosphorylation by Binding to the Catalytic Site: Studies in Intact Cells Another AMPK Inhibitor, MRT199665, Also Causes Paradoxical Activation in Cells Our results show that SU6656 activates AMPK but not by inhibition of...
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