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Articles

mRNA-1273 SARS-CoV-2 vaccination in people with HIV: an immune correlates analysis of CD4 + T cell responses in the multicenter CoVPN 3008 observational study

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By Sharon Khuzwayo, Bo Zhang, Valentin Voillet, Lindsay N. Carpp, James Peng, Jiani Hu, Katharine Schwedhelm, Erica Smit, Craig A Magaret, Zhe Chen, Siyu Heng, Yutong Jin, Peter Elyanu, Asa Tapley, Aaron Hudson, Sinethemba Bhebhe, Haajira Kaldine, Prudence Kgagudi, Tandile Hermanus, Jessica Andriesen, April K. Randhawa, Leigh H. Fisher, Manuel Villaran, Margaret Yacovone, Taraz Samandari, Zvavahera M. Chirenje, Sharlaa Badal-Faesen, William Brumskine, Rodney Dawson, Sinead Delany-Moretlwe, Andreas Henri Diacon, Samantha Fry, Katherine Gill, Mina C. Hosseinipour, Craig Innes, Steve Innes, Dishiki Kalonji, Margaret P Kasaro, Noel Kayange, William Kilembe, Fatima Laher, Joseph Makhema, Vongane Maluleke, Cissy Kityo Mutuluuza, Pamela Mda, Tumelo Moloantoa, Nivashnee Naicker, Vimla Naicker, Annet Nanvubya, Harriet Nuwagaba-Biribonwoha, Walter Otieno, Elsje Louise Potgieter, Disebo Potloane, Yashna Singh, Myron Cohen, James G. Kublin, Lawrence Corey, Glenda Gray, Yunda Huang, Nyaradzo Mgodi, Sufia Dadabhai, Philip Kotze, Nigel J. Garrett, John Hural, Guido Ferrari, David C. Montefiori, Penny Moore, Georgia Tomaras, Nonhlanhla N. Mkhize, Stephen De Rosa, M. Juliana McElrath, Peter Gilbert, Erica Andersen-Nissen, Faatima Laher Omar, Jia Jin Kee, Laura Polakowski, Soritha Coetzer, Mubiana Inambao, Priya Kassim, Ethel Kamuti, Moelo Malahleha, Matsontso Mathebula, Grace Mboya, Kirsten McHarry, Essack Mitha, Sibekezelo Msomi, Zelda Punt, Mohammed Siddique Tayob, Yacoob Vahed, Joel Maena, Linda- Gail Bekker
| Nature Verified
Abstract T cell correlates of COVID-19 risk are poorly defined, particularly in people with HIV (PWH). CoVPN 3008 (NCT05168813) Part A was a prospective 14,002-participant cohort study that administered one or two doses of mRNA-1273 COVID-19 vaccine, depending on baseline SARS-CoV-2 serostatus, in participants (83% PWH) in sub-Saharan Africa. Participants self-monitored for prespecified COVID-19 symptoms, defined by Centers for Disease Control and Prevention symptom criteria.
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