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Articles by Fangda Li
Engineered probiotics for tumor-targeted combination chemoimmunotherapy
Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract Achieving tumor-specific delivery and sustained activation of both cytotoxic and immune-modulating agents remains a critical challenge in chemoimmunotherapy.
Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy in preclinical mouse models
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Bladder cancer is often treated with Bacillus Calmette-Guérin immunotherapy, a bacterial therapy delivered intravesically; however, its effect on the host humoral immune response during immune checkpoint blockade (ICB) is not known, limiting its potential to improve therapy. Here, Rouanne et al.
Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy
Abstract The intratumoral microbiome has recently emerged as a new hallmark of cancer, with implications for response or resistance to therapy. While bacteria can either promote or inhibit cancer growth, intratumoral bacteria can also be engineered using synthetic biology to remodel the tumor microenvironment. Here, we engineered the probiotic bacterium E. coli Nissle 1917 (EcN) to express the human chemokine CXCL13, a critical component of germinal center (GC) formation.
Erratum for the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al.
In the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al., there were two figure errors. The SARS-CoV-2 N blot from Fig. 1G was mistakenly duplicated from the SARS-CoV-2 N blot in Fig. 5C. The images representing the uninfected A549-ACE2 in fig. S3B were inadvertently duplicated from a different experiment (shown in Fig. 3D) than the other images in the panel. The SARS-CoV-2 N blot in Fig.
Erratum for the Research Article “Circulating KLRG1+ long-lived effector memory T cells retain the flexibility to become tissue resident” by E. D. Lucas et al.
eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter.
The acid-sensing receptor GPR65 on tumor macrophages drives tumor growth in obesity
Editor’s summary Obesity is a risk factor for the development of several types of cancer, but how obesity contributes to tumorigenesis remains incompletely understood. Using a mouse model of colon cancer, Bagchi et al. found that tumor-associated macrophages (TAMs) accumulate and drive tumor growth in obese mice. Obesity-associated accumulation of oleic acid enhanced tumor acidity and suppressed TAM inflammatory responses.
Programmable bacteria synergize with PD-1 blockade to overcome cancer cell-intrinsic immune resistance mechanisms
Editor’s summary Engineering bacteria to release therapeutic candidates within tumors circumvents the severe toxicity associated with systemic delivery and is a promising strategy for immunotherapy. Li et al. engineered a strain of E. coli to express the cytokine IFN-γ within the tumor core (SLIC–IFN-γ). In mice, intratumoral injection of SLIC–IFN-γ promoted antitumor immunity by polarizing tumor-associated myeloid cells and activating cytotoxic T cells.
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury
Editor’s summary Chitin is an insoluble polysaccharide derived from sources like cockroaches and molds commonly found in inhaled airborne particles. Jung et al. investigated how exposure to environmental chitin potentially contributes to lung homeostasis, inflammation, and repair in models of viral infection and lung injury.
Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection
Abstract Amphiregulin (Areg), a growth factor produced by regulatory T (Treg) cells to facilitate tissue repair/regeneration, contains a heparan sulfate (HS) binding domain. How HS, a highly sulfated glycan subtype that alters growth factor signaling, influences Areg repair/regeneration functions is unclear. Here we report that inhibition of HS in various cell lines and primary lung mesenchymal cells (LMC) qualitatively alters downstream signaling and highlights the existence of HS-dependent vs.
Probiotic-guided CAR-T cells for solid tumor targeting
Published In Science Volume 382 | Issue 6667 13 October 2023 Article versions Submission history Received: 16 August 2022 Accepted: 24 August 2023 Published in print: 13 October 2023 Permissions Request permissions for this article. Acknowledgments We thank M. Sadelain for providing the ffLuc+ Nalm6 acute lymphoblastic leukemia cell line, R. Schwabe for providing the Huh7 hepatoma cell line, and S. Acharyya for providing the PYMT-derived cell line. We thank N.
Probiotic neoantigen delivery vectors for precision cancer immunotherapy
Abstract Microbial systems have been synthetically engineered to deploy therapeutic payloads in vivo1–4. With emerging evidence that bacteria naturally home to tumors5–7 and modulate anti-tumor immunity8,9, one promising application is the development of bacterial vectors as precision cancer vaccines10–12. In this study, we engineered probiotic E.
Long-Term Outcomes and Potential Risk Factors for Endovascular Repair of Aortic Pseudoaneurysms in Vascular Behçet’s Disease
This study aimed to analyse long-term outcomes and risk factors for endovascular repair of aortic pseudoaneurysms in patients with vascular Behçet’s disease (BD). Medical records of 26 aortic vascular BD patients who underwent endovascular treatment at the vascular department of Peking Union Medical College Hospital between January 2002 and December 2021 were retrospectively reviewed. Erythrocyte sedimentation rate (ESR) and C-reactive protein were used to assess BD activity.
Deep Learning with Adaptive Attention for Seismic Velocity Inversion
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