Fangjun Chen
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Articles by Fangjun Chen
Clinicopathological and molecular characteristics of primary pulmonary choriocarcinoma: a case report and systematic review
Abstract Primary pulmonary choriocarcinoma (PPC) is an exceptionally rare and aggressive non-gestational trophoblastic malignancy for which no standard treatment has been established. We report a 61-year-old man with PPC and brain metastases who received intracranial radiotherapy and first-line albumin-bound paclitaxel plus cisplatin, followed by etoposide, capecitabine, and camrelizumab after disease progression.
Enhancing Agrobacterium-Mediated Hairy Root Transformation Efficiency in Peanut Through the Application of GRF, GIF and WOX Genes
You are already at the latest version Peanut (Arachis hypogaea L.) is a major oil and economic crop, yet genetic transformation remains inefficient and time-consuming, hindering functional genomics and molecular breeding.
Short-term exposure to ambient air pollution and emergency ambulance dispatches for precipitous labor: a time-series study in Guangzhou, China
Abstract The association between maternal exposure to air pollutants and precipitous labor is still unclear.Emergency ambulance dispatch (EAD) data provide a near real-time, population-wide indicator of acute health exacerbations, enabling the detection of acute population health responses to air quality fluctuations.We examine the relationship between EADs for precipitous labor and short-term exposure to six criteria ambient pollutants using a time-series study.
Clinical application and institutional governance of foods for special medical purposes in medical institutions of eastern coastal China: a cross-sectional study
Abstract Introduction: Despite the established clinical value of Foods for Special Medical Purposes (FSMP) in improving patient outcomes, their integration into the Chinese healthcare system remains highly uneven.
Mendelian Randomization Analysis Reveals Causal Effects of Circulating Metabolites on Hyperaldosteronism
1 Introduction Hyperaldosteronism is a frequent cause of secondary hypertension, affecting approximately 5% ~ 10% of hypertensive patients, and is associated with target organ involvement and damage (Funder et al. 2016). Hyperaldosteronism is characterized by the overproduction of aldosterone, primarily due to aldosterone-producing adenomas or bilateral adrenal hyperplasia, and is termed endocrine hypertension.
Bidirectional mendelian randomization analysis of the genetic associat
Chenyang Zhao,1,2,* Fangjun Chen,3,* Qiong Li,1,2 Lixiu Peng,1 Chaoyan Yue4 1Department of Obstetrics and Gynecology, The First People’s Hospital of Chenzhou, Chenzhou, People’s Republic of China; 2Department of Obstetrics and Gynecology, Jinan University, Guangzhou, People’s Republic of China; 3Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 4Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of...
The relationship between hypothyroidism and pneumonia and possible pre
Back to Journals » International Journal of General Medicine » Volume 18 Original Research Infectious Diseases Authors Hao Y , Zheng H, Xiang W , Chen F , Qiang G Received 21 March 2025 Accepted for publication 11 August 2025 Published 19 August 2025 Volume 2025:18 Pages 4519—4533 DOI https://doi.org/10.2147/IJGM.S529705 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Sandul Yasobant Yang Hao,1,* Hanyu...
FAM65A promotes the progression and growth of lung squamous cell carcinoma in vivo and vitro - BMC Cancer
Gene expression profiles of GSE75037 [34], GSE67061 [35], GSE18842 [36], GSE2088 [37], GSE161533 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi) datasets sourced from Gene Expression Omnibus (GEO) were downloaded to evaluate FAM65A expression in LSCC. RNA sequencing data of 502 lung cancer and 49 normal samples with relevant clinical information were accessed from The Cancer Genome Atlas (TCGA) database.
Genes | Free Full-Text | Comparative Analysis of Six Chloroplast Genomes in Chenopodium and Its Related Genera (Amaranthaceae): New Insights into Phylogenetic Relationships and the Development of Species-Specific Molecular Markers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Discovery of 2,3-Dihydro[1,4]dioxino[2,3-g]benzofuran Derivatives as Protease Activated Receptor 4 (PAR4) Antagonists with Potent Antiplatelet Aggregation Activity and Low Bleeding Tendency
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Med. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Discovery of 2,3-Dihydro[1,4]dioxino[2,3-g]benzofuran Derivatives as Protease Activated Receptor 4 (PAR4) Antagonists with Potent Antiplatelet Aggregation Activity and Low Bleeding Tendency
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Med. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Using Virtual Reality in the Care of Older Adults With Dementia: A Randomized Controlled Trial
Introduction According to a special research report of the Standing Committee of the National People's Congress of China, China's population of individuals aged ≥60 years reached 267 million in 2021, accounting for 18.9% of the total population (). China is the only country with an older adult population >200 million.
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors
BACKGROUND. Recent genomic and bioinformatic technological advances have made it possible to dissect the immune response to personalized neoantigens encoded by tumor-specific mutations. However, timely and efficient identification of neoantigens is still one of the major obstacles to using personalized neoantigen-based cancer immunotherapy. METHODS.
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