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Farahnaz Ranjbarian on Muck Rack

Farahnaz Ranjbarian

As seen in: BioRxiv, The Journal of Biological Chemistry
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Articles

The specific AMPK activator A-769662 ameliorates pathological phenotypes following mitochondrial DNA depletion

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By Gustavo Carvalho, Bruno Repolês, Farahnaz Ranjbarian, Isabela Mendes
| BioRxiv
Abstract AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis that also plays a role in preserving mitochondrial function and integrity. Upon a disturbance in the cellular energy state that increases AMP levels, AMPK activity promotes a switch from anabolic to catabolic metabolism to restore energy homeostasis.
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Giardia intestinalis deoxyadenosine kinase has a unique tetrameric structure that enables high substrate affinity and makes the parasite sensitive to deoxyadenosine analogues

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By Farahnaz Ranjbarian, Kasturika Shankar, Karim Rafie, Sascha Krakovka
| BioRxiv
Abstract Giardia intestinalis is a protozoan parasite causing giardiasis, a severe, sometimes even life-threatening, diarrheal disease. Giardia is one of only a few known organisms that lack de novo synthesis of DNA building blocks, and the parasite is therefore completely dependent on salvaging deoxyribonucleosides from the host.
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Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine

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By Anders Hofer, Munender Vodnala, Farahnaz Ranjbarian, Anna Pavlova
| The Journal of Biological Chemistry Verified
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T. brucei cultivated in the presence of deoxyadenosine accumulates high levels of dATP in an adenosine kinase-dependent process and dies within a few hours. Here we show that T.
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