Farhang Aliakbari

ALS amyotrophic lateral sclerosis BSA Bovine serum albumin EGFP enhanced green fluorescent protein EVs extracellular vesicles FBS fetal bovine serum FTLD frontotemporal lobar degeneration HEK293 human embryonic kidney 293 cells PBS phosphate buffered saline PC12 pheochromocytoma 12 cells SD rats Sprague–Dawley rats SEC size exclusion chromatography SFCA surfactant-free cellulose acetate TDP-43 Tar DNA-binding protein 43 Introduction The hallmark of a broad range of neurodegenerative disorders...

Research Article NEUROSCIENCE Farhang Aliakbari https://orcid.org/0000-0002-0928-3743 morshedi@nigeb.ac.ir, Kimia Marzookian, [...] , Soha Parsafar, Hamdam Hourfar, [...] , Zahra Nayeri https://orcid.org/0000-0003-3453-3190, Arghavan Fattahi https://orcid.org/0000-0001-6248-4344, Mohammad Raeiji, Narges Nasrollahi Boroujeni, Daniel E.

Abstract The blood-brain barrier (BBB) is a highly developed endothelial microvessel network extended to almost all parts of the central nervous system (CNS) that tightly seals cell-to-cell contacts and plays a critical role in maintaining CNS homeostasis. It also protects neurons from factors present in systemic circulation and prevents pathogens from entering the brain. Conversely, BBB disruption can initiate multiple pathways of nerve damage.