Fariza Mezine

Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Patients with colorectal carcinoma benefit from early detection and identification of premalignant lesions, yet the role of the tumor immune microenvironment in early carcinogenesis is unknown. Here, Morgand et al.

Correction to: Nature https://doi.org/10.1038/s41586-025-09847-6 Published online 13 November 2025 In the version of the article initially published, in Extended Data Fig. 8e, the frequencies in graph iv were DN: 7.05%, DP: 67.2%, SPCD4: 10.8%, SPCD8: 14.9% but should have been DN: 18.8%, DP: 2.56%, SPCD: 0.32%, SPCD8: 78.4%. In Extended Data Fig. 8f, in graph iii, hCD45 was 48% but should have been 0.48%. These corrections have been made to the HTML and PDF versions of the article.

1 Introduction Here, we analyze the complement activation profile in the second, live porcine-to-human heart transplant [1]. Xenotransplantation offers a promising solution to the global organ shortage crisis. However, innate immune barriers—particularly the complement system—remain challenging. Complement can trigger hyperacute rejection and thrombotic injury in xenograft models, even in the absence of adaptive immune responses [2, 3].