Fausto Rodriguez

Access at https://isn-slidearchive.org/?col=ISN&fol=Archive&file=ID-9336200.svs. 1 CLINICAL HISTORY A 66-year-old male with a history of hypertension presented with acute vision loss in his left eye for a few weeks. He had a history of blurred vision in the left eye, which had been treated for suspected acute retinal necrosis/herpetic retinitis with intravitreal valacyclovir and ganciclovir and topical corticosteroids at an outside institution, but he had been lost to follow up for several months.

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An 8-year-old boy presented with a 2-week history of worsening right-sided headache and left-sided jerking movements. Symptoms were associated with vomiting, photophobia, phonophobia, and diplopia but no loss of consciousness. cEEG demonstrated increased voltage on the right but no evidence of seizures. Brain MRI demonstrated a large right frontoparietal mass (figure 1). The pathologic findings were compatible with DICER1-associated pleomorphic spindle cell sarcoma (figure 2).