Faye-Marie Vassel

Abstract The rapid deployment of generative language models has raised concerns about social biases affecting the well-being of diverse consumers. The extant literature on generative language models has primarily examined bias via explicit identity prompting. However, prior research on bias in language-based technology platforms has shown that discrimination can occur even when identity terms are not specified explicitly.

Significance Mutagenic translesion synthesis (TLS) allows cells to increase their survival after DNA damage by bypassing lesions that normally block DNA replication but at the cost of introducing mutations. Interfering with this TLS pathway genetically or with the small molecule inhibitor JH-RE-06 has been shown to improve cisplatin chemotherapy by suppressing tumor growth and enhancing survival in mouse xenograft tumor models.