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Feichi Chen on Muck Rack

Feichi Chen

As seen in: Nature, Wiley Online Library
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Articles

1-deoxysphinganine promoted microglial glycolytic reprogramming and neuroinflammation in alzheimer’s disease

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By Tao Ye, Xinhuang Lv, Zheyu Fang, Qiyao Li, Feichi Chen, Yiyao Dong, Kun Xiang, Yao Yang, Jing Yi Sun, Kuan-Pin Su, Jiaming Liu, Conghui Dai, Quang Le Do
| Nature Verified
Abstract Recent evidence suggests that microglial activation, driven by a metabolic shift towards glycolysis, was involved in the pathogenesis of Alzheimer’s disease (AD). Although sphingolipid (SL) dysregulation has been linked to AD, the role of 1-deoxysphinganine (deoxySO), an atypical and neurotoxic SL, on microglial glycolytic reprogramming remains unclear. We measured serum deoxySO levels in AD patients and evaluated their association with cognitive performance.
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Molecular Dynamics Analysis of the Structural Behavior of Aluminum Ion in the Slag of CaO-SiO2-Al2O3-Li2O System

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By Peiyao Guo, Yi Min, Shiyan Jiao, Feichi Chen
| Wiley Online Library Verified
To further understand the structural behavior of Al3+ in the CaO-SiO2-Al2O3-Li2O system melt, molecular dynamics simulations were used to analyze the microstructure of the melt under different basicity conditions. The results showed that the bond length of Al-O was longer than that of Si-O and was less stable than Si-O. The stability of the [AlO4]5- tetrahedral structure was lower than that of the [SiO4]4- tetrahedral structure.
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