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Feiyin Chen on Muck Rack

Feiyin Chen

As seen in: Frontiers in Immunology
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Articles

Virus-driven remodeling of the immune microenvironment and response to immune checkpoint inhibitors: the infection– immunity–cancer crosstalk

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By Guangying Wang, Runda Zhao, Zhuoqi Liu, Xiaohong Yang, Daya Luo, Feiyin Chen
| Frontiers in Immunology
Abstract Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic landscape of diverse solid tumors; however, concurrent viral infections significantly influence their efficacy and safety profiles. By driving persistent antigen exposure, inducing T cell exhaustion, and remodeling the immunosuppressive tumor microenvironment (TME), viruses extensively reconfigure tumor immune landscapes, leading to marked heterogeneity in responses to immunotherapy.
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