Felix Viebahn

Enhanced weathering in the US Corn Belt delivers carbon removal with agronomic benefits David J. Beerling https://orcid.org/0000-0003-1869-4314 d.j.beerling@sheffield.ac.uk, Dimitar Z. Epihov https://orcid.org/0000-0001-5711-5480, Ilsa B. Kantola, +13 , Michael D. Masters, Tom Reershemius https://orcid.org/0000-0003-3512-6693, Noah J. Planavsky, Christopher T. Reinhard https://orcid.org/0000-0002-2632-1027, Jacob S. Jordan, Sarah J.

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Significance Apoptosis is triggered by initiator caspase activation, which is thought to rely on a multimeric machinery known as the apoptosome. The initiator caspase-9 in mammals is activated by the Apaf-1 apoptosome. Similarly, Dronc in Drosophila is thought to be activated by the Dark apoptosome. The molecular mechanism by which an initiator caspase is activated by its corresponding apoptosome remains elusive. In this study, we provide key insights into how Dark mediates Dronc activation.