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Articles by Feng Ma
Author Correction: HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
Correction to: Nature Structural & Molecular Biology https://doi.org/10.1038/s41594-026-01871-y, published online 28 September 2026. In the version of this article initially published, the representative TUNEL staining image for control-treated Herc4−/− mice in Fig. 6g was incorrect. The figure has been updated in the HTML and PDF versions of the article. For comparison, the original and revised image and raw data are available as Supplementary Information accompanying this amendment.
Multiproperty optimization of therapeutic antibodies through sequence editing via large language model and reinforcement learning
Abstract Discovering antibodies with multiple beneficial properties is essential for therapeutic drug development, but experimentally identified antibodies require further optimization. Joint optimization remains challenging because sequence space is vast, annotations are sparse and property tradeoffs are common. Herein, we propose AbOptimizer, a reinforcement learning framework for multiproperty antibody optimization through parallel multisite sequence editing.
HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death
Abstract TNF can activate both prosurvival and prodeath signaling downstream of tumor necrosis factor receptor 1 (TNFR1). Survival signaling originates from TNFR1-containing membrane-bound complex I, while death signaling is driven by cytosolic complex II. Receptor-interacting protein kinase 1 (RIPK1) is a central component of both complexes but the molecular switch converting RIPK1 from a prosurvival scaffold in complex I to a prodeath kinase in complex II has remained elusive.
Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis
Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptosis in pancreatic acinar cells has been implicated in AP pathogenesis, here we uncover an indispensable role for macrophage RIPK3 in driving AP-associated inflammation.
Green signals in credit pricing: proactive government response to biodiversity risk and credit spreads
Abstract This study examines the impact of Proactive Government Response to Biodiversity Risk (PGBR) on the credit spreads of Local Government Financing Vehicle (LGFV) bonds. Based on a textual analysis of government work reports from 2015 to 2023, a PGBR index is constructed.
Effects of Tetradecane Direct Incorporation on Asphalt Properties: A Molecular Dynamics and Experimental Approach
Get full access to this article View all available purchase options and get full access to this article. Data Availability Statement Some or all data, models, or code that support the findings of this study are available from the corresponding author upon reasonable request. Acknowledgments This study was supported by National Key R&D Program of China (No. 2023YFB2604600). Author Contributions Yingjie Hou: Writing – original draft. Feng Ma: Funding acquisition. Zhen Fu: Project administration.
A viable kinase-inactive RIPK3 D143N mouse model reveals its scaffold function in driving TNF-induced inflammatory disorder - Cell Death Discovery
Abstract RIPK3 is a key regulator of necroptosis, but the specific roles of its kinase-dependent and -independent functions in disease pathogenesis remain poorly understood. Here, we generated and characterized RIPK3 D143N kinase-dead knock-in mice, a novel kinase-inactive model that selectively disrupts RIPK3 kinase activity without inducing spontaneous apoptosis.
Trait Hierarchy and Interactive Effects Govern Seed Fate in Rodent‐Mediated Dispersal: Insights from Coat Thickness, Nutrients, and Tannins
1 Introduction Seed dispersal by rodents is a keystone ecological process that shapes plant community structure, forest regeneration, and ecosystem functioning (Forget et al. 2005; Vander Wall et al. 2005; Beckman and Sullivan 2023). In subtropical evergreen broad-leaved forests, scatter-hoarding rodents such as Leopoldamys edwardsi act as both seed predators and dispersers, influencing the fate of seeds from co-occurring plant species (Zhang et al. 2008; Yang et al. 2018, 2023).
An Enhanced Gray Wolf Optimizer and Its Application to Parameter Calibration in Open-Channel Flow
Get full access to this article View all available purchase options and get full access to this article. Data Availability Statement Some or all data, models, or code that support the findings of this study are available from the corresponding author upon reasonable request.
Rheological and Micro Properties of High-Viscosity Binder–Incorporated Polyphosphoric Acid and Rock Asphalt | Journal of Materials in Civil Engineering | Vol 38, No 2
Practical Applications This study investigates the effects of polyphosphoric acid (PPA) and North American rock asphalt (NA–RA) on the performance of modified asphalt (SBS/CR composite modified asphalt). The experiments show that both PPA and NA–RA effectively improve the internal structure of the asphalt, enhancing its high- and low-temperature properties.
Two-parameter conceptual instantaneous unit hydrograph method with flood peak delay time and shape coefficient
Abstract The unit hydrograph model is a simple and effective tool for hydrological forecasting in small- and medium- sized basins with limited data. This study proposes a novel two-parameter Conceptual Instantaneous Unit Hydrograph (CIUH) model for flood forecasting in data-scarce basins. Unlike traditional CIUH methods (e.g. Nash’s model) with abstract parameters, our model uses physically meaningful variables: flood peak delay time (Tp) and shape coefficient (SC).
Two Novel β‐Casein Iron‐Chelating Peptides: Isolation, Identification, Prediction of Iron Binding Modes, and Enhancement Intestinal Iron Absorption Activity
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description jfds70258-sup-0001-SuppMat.pdf102.1 KB Table S1. The chromatographic conditions for the HPLC separation. Table S2. The 232 peptides derived from the M4 fraction were identified by HPLC-MS/MS. References , , , , and . 2021.
Study on the effect of load on the structural response of projectile during penetration process - Scientific Reports
Abstract To delve deeper into the dynamic behaviors of a typical projectile structure subjected to multi-pulse loading, this paper focuses on the scenario of a projectile positively penetrating an equally spaced, multi-layer target. It proceeds by designing multi-pulse excitation loads that vary in temporal intervals and amplitudes.
ShipMOT: A Robust and Reliable CNN-NSA Filter Framework for Marine Radar Target Tracking
1. Introduction In maritime transportation, the continuous tracking and monitoring of ship positions near ports and in crowded waters is of great significance for ensuring ship navigation safety and improving the efficiency of port operations. Marine radars (MR) are extensively utilized in the fields of ship navigation, collision avoidance, and ship surveillance [1,2].
Preliminary Multi-Objective Optimization of Mobile Drip Irrigation System Design and Deficit Irrigation Schedule: A Full Growth Cycle Simulation for Alfalfa Using HYDRUS-2D
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Prediction and calibration of black soil modeling parameters based on response surface methodology and machine learning algorithms
Abstract Five machine learning algorithms Decision Tree, Random Forest, Support Vector Machine (SVM), KNN, and XG Boost were used to calibrate the discrete element contact parameters of the black soil by combining the measured data on the black soil and the simulated pile load test. Firstly, the physical parameters of the black soil and the angle of stacking were determined based on physical tests.
Ship Contour: A Novel Ship Instance Segmentation Method Using Deep Snake and Attention Mechanism
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Exploring the Therapeutic Potential of MIR‐140‐3p in Osteoarthritis: Targeting CILP and Ferroptosis for Novel Treatment Strategies
1 Introduction Osteoarthritis (OA) is a prevalent and debilitating condition that causes pain, reduces quality of life and imposes significant healthcare costs [1, 2]. Despite the availability of current treatments, OA remains highly prevalent, particularly among individuals over 50 years of age [3].
Redefining Aquaculture Safety with Artificial Intelligence: Design Innovations, Trends, and Future Perspectives
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Oil Shocks and the Financial Markets: A Review
Conflicts of Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. References , , and . 2013. “Oil Price Shocks and the Stock Market: Evidence From Japan.” Energy Journal 34, no. 2: 199–222. , , and . 2011. “Oil Price Shocks and Economic Growth in Nigeria: Are Thresholds Important?” OPEC Energy Review 35, no. 4: 308–333. , , and . 2012.
RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring - Cellular & Molecular Immunology
Abstract Spliceosome dysfunction and aberrant RNA splicing underline unresolved inflammation and immunopathogenesis. Here, we revealed the misregulation of mRNA splicing via the spliceosome in the pathogenesis of rheumatoid arthritis (RA).
YOSMR: A Ship Detection Method for Marine Radar Based on Customized Lightweight Convolutional Networks
1. Introduction The continuous surveillance of ships within ports and designated navigational waterways represents a pivotal undertaking, serving to provide regulatory personnel and ship operators with instantaneous insights into the state of maritime passages [1]. As a widely deployed monitoring apparatus, a shore-based marine radar enables the continuous detection of ship targets in wide-ranging water areas under adverse weather conditions (e.g., rain or fog) and poor nighttime visibility.
Can dynamic contrast-enhanced MR imaging based on radiomics improve the diagnostic efficiency of clinically significant prostate cancer?
Introduction Prostate cancer (PCa) ranks as the second most prevalent cause of cancer-related mortality among men (Siegel et al, 2015). Non-clinically significant prostate cancer (non-csPCa) demonstrates a low incidence of progression and offers potential for cure. Accurately identifying clinically significant lesions is essential for selecting suitable treatment modalities and reducing the risks of overtreatment or ineffective outcomes (Ahmed et al, 2012).
Long Non-Coding RNA AGAP2-AS1: A Comprehensive Overview on Its Biological Functions and Clinical Significances in Human Cancers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Hybrid forecasting of crude oil volatility index: The cross‐market effects of stock market jumps
REFERENCES , , , & (2021). The US equity sectors, implied volatilities, and COVID-19: What does the spillover analysis reveal? Resources Policy, 72, 102102. https://doi.org/10.1016/j.resourpol.2021.102102 , & (1998). Answering the skeptics: Yes, standard volatility models do provide accurate forecasts. International Economic Review, 39(4), 885–905. https://doi.org/10.2307/2527343 , , & (2007). Roughing it up: Including jump components in the measurement, modeling, and forecasting of return volatility.
Dissecting climate change risk and financial market instability: Implications for ecological risk management
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. REFERENCES , , , , & (2022). A quantity-based approach to constructing climate risk hedge portfolios (Technical report). National Bureau of Economic Research. , , , & (2009). Winter heating or clean air? Unintended impacts of China's Huai river policy. American Economic Review, 99(2), 184–190. , & (2004). Is all that talk just noise? The information content of Internet stock message boards. Journal of Finance, 59(3), 1259–1294.
MrisNet: Robust Ship Instance Segmentation in Challenging Marine Radar Environments
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Assessing the effects of agricultural waste returning on soil moisture characteristics
REFERENCES 1, , , et al. Agro-waste to sustainable energy: a green strategy of converting agricultural waste to nano-enabled energy applications. Sci Total Environ. 2023; 875:162667. 2, , , et al. Analysis of composting standards at home and abroad and its enlightenment to China. Trans Chin Soc Agric Eng. 2019; 35(12): 265-271. 3, , , et al. Utilization of agricultural waste biomass and recycling toward circular bioeconomy. Environ Sci Pollut Res. 2023; 30(4): 8526-8539. 4, , .
Special Issue: “Innate Immunity to Virus Infection, 1st Edition”
Frequent outbreaks of emerging and re-emerging pathogenic viruses have become one of the major challenges for global public health. As the first line of defense, the innate immune system plays a vital role in fighting the invasion of pathogenic microorganisms.
Optimal Discrete Element Parameters for Black Soil Based on Multi-Objective Total Evaluation Normalized-Response Surface Method
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Intensification of drought propagation over the Yangtze River basin under climate warming
Filename Description joc8165-sup-0001-Supinfo.docxWord 2007 document , 821.5 KB Data S1. Supporting Information. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Genesis and Geological Significance of Siderite in the First Member of the Nantun Formation of Dongming Sag, Hailar Basin
1. Introduction Siderite is an important iron-bearing carbonate mineral often found in marine or lacustrine settings, with FeCO3 as its main component [1,2,3,4]. Siderite (FeCO3, density 3960 kg/m3; Hurlbut, 1971) is a brownish translucent mineral crystallizing in the same hexagonal (rhombohedral) lattice as calcite [5]. Large amounts will rarely be attained in an ore deposit because Fe carbonates tend to have a wide range of substitution of Mn, Mg, and Ca for bivalent Fe [6].
An Energy-Efficient Optimal Operation Control Strategy for High-Speed Trains via a Symmetric Alternating Direction Method of Multipliers
Abstract : Train operation control is of great importance in reducing train operation energy consumption and improving railway operation efficiency. This paper investigates the design of optimal control inputs for multiple trains on a single railway line with several stations. Firstly, a distributed optimal control problem for multiple train operation is formulated to reduce the energy consumption and improve the punctuality of trains.
Predicting the Potential of China’s Geothermal Energy in Industrial Development and Carbon Emission Reduction
Open AccessArticle by 1,2, 1,2,*, 1,2, 1,2, 1,2 and 1,2 1 Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang 050061, China 2 Technology Innovation Center of Geothermal & Hot Dry Rock Exploration and Development, Ministry of Natural Resources, Shijiazhuang 050061, China * Author to whom correspondence should be addressed.
Forecasting the Asian stock market volatility: Evidence from WTI and INE oil futures
REFERENCES , & (2021). Volatility transmissions across international oil market, commodity futures and stock markets: Empirical evidence from China. Energy Economics, 93, 104741. , , & (2021). Modeling the volatility of TOCOM energy futures: A regime switching realized volatility approach. Energy Economics, 93, 104434. , , , & (2017). “Asian premium” or “North Atlantic discount”: Does geographical diversification in oil trade always impose costs? Energy Economics, 66, 411–420. , , & (2012).
Influencing factors and evaluation methods of reinforcement effect of fiber‐modified asphalt binder
RESEARCH ARTICLE Funding information: the National Key R&D Program of China, Grant/Award Number: NO.2018YFB1600200; the Special Fund for Basic Scientific Research of Central Colleges, Chang'an University, Grant/Award Number: NO.300102211504; National Natural Science Foundation of China, Grant/Award Number: 5203000548; Chang'an University Abstract The reinforcement of fiber is the linchpin of improving the strength of the asphalt binder and its mixture.
A Novel Ship Collision Avoidance Awareness Approach for Cooperating Ships Using Multi-Agent Deep Reinforcement Learning
1. Introduction Under the trend of economic globalization, maritime transportation system plays an important role in the international supply chain [1,2,3,4]. Especially maritime autonomous surface ships (MASS) are considered as a promising area in the maritime transportation system.
Correction: Enhanced 1.54 μm luminescence of a perfluorinated erbium complex sensitized by perfluorinated Pt(II) and Zn(II) phthalocyanines with 980 nm emission
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Enhanced 1.54 μm luminescence of a perfluorinated erbium complex sensitized by perfluorinated Pt(II) and Zn(II) phthalocyanines with 980 nm emission
Enhanced 1.54 μm luminescence of a perfluorinated erbium complex sensitized by perfluorinated Pt(ii) and Zn(ii) phthalocyanines with 980 nm emission† Hongfei Li,*ab Xiaoqi Liu,a Chen Lyu, a Feng Ma,c Huanqing Ye,a Peter. B. Wyattd and William P.
Enhanced 1.54 µm luminescence of perfluorinated erbium complex sensitized by perfluorinated Pt(II) and Zn(II) phthalocyanines with 980 nm emission
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Erratum for Chen et al., “Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate”
Erratum Qi Chen, Jin Wu, Qing Ye, Feng Ma, Qian Zhu, Yan Wu, Chao Shan, Xuping Xie, Dapei Li, Xiaoyan Zhan, Chunfeng Li, Xiao-Feng Li, Xiaoling Qin, Tongyan Zhao, Haitao Wu, Pei-Yong Shi, Jianghong Man, Cheng-Feng Qin DOI: 10.1128/mBio.00433-19 ERRATUM Volume 9, issue 5, e01683-18, 2018, https://doi.org/10.1128/mBio.01683-18. The fourteenth author’s name was misspelled. The byline should appear as shown above. Copyright © 2019 Chen et al.
Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate
ABSTRACTGlioblastoma (GBM) is the deadliest type of brain tumor, and glioma stem cells (GSCs) contribute to tumor recurrence and therapeutic resistance. Thus, an oncolytic virus targeting GSCs may be useful for improving GBM treatment. Because Zika virus (ZIKV) has an oncolytic tropism for infecting GSCs, we investigated the safety and efficacy of a live attenuated ZIKV vaccine candidate (ZIKV-LAV) for the treatment of human GBM in a GSC-derived orthotopic model.
Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System
Induction of type I IFN (IFN-I) is essential for host antiviral immune responses. However, IFN-I also plays divergent roles in antibacterial immunity, persistent viral infections, autoimmune diseases, and tumorigenesis. IFN regulatory factor 3 (IRF3) is the master transcription factor that controls IFN-I production via phosphorylation-dependent dimerization in most cell types in response to viral infections and various innate stimuli by pathogen-associated molecular patterns (PAMPs).
Essence BeautyBox - Contest Rules
Open only to those who follow @essencebox on Twitter, provided that entrant is a legal U.S. Resident age 18 or older at the time of entry. Limited to one entry per Twitter account. Void where prohibited by law. ESSENCE beauty editors will select the best picture perfect look (50% originality and 50% creativity) shared via the custom hashtag # PicturePerfectGiveaway to @essencebox. There will be (5) winners in total.
Unprecedented 2D Copper(I)-Cyanide Complex with 20-Member Metal Ring: the Effect of the Co-ligand 4,5-diazafluoren-9-one
Hydrothermal reaction of Cu(NO3)2, 4,5-diazafluoren-9-one (L) and K3[Fe(CN)6], which is used as environment friendly cyanide source, produces a two-dimensional copper cyanide complex Cu10(CN)10L4 (1). In the complex, the L ligands act as corner and bridges ligands simultaneously. With the help of the corner ligands, infinite Cu(CN)∞ chains are formed.
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