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Fengtian He

As seen in: Nature
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Articles

Deacetylation of ANXA2 by SIRT2 desensitizes hepatocellular carcinoma cells to donafenib via promoting protective autophagy - Cell Death & Differentiation

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By Liangbo Sun, Yingxue Hao, Fengtian He, Haojun Xiong
| Nature Verified
Abstract Hepatocellular carcinoma (HCC) is one of the most lethal forms of cancer globally. HCC cells frequently undergo macroautophagy, also known as autophagy, which can lead to tumor progression and chemotherapy resistance. Annexin A2 (ANXA2) has been identified as a potential therapeutic target in HCC and is involved in the regulation of autophagic process. Here, we for the first time showed that ANXA2 deacetylation plays a crucial role in donafenib-induced autophagy.
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F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression - Nature Communications

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By Feng LI, Hongqiang Yu, YuJun Zhang, Yuanhang Ma, Xinlei Chen, Jie Zhang, Liangbo Sun, Rui Guo, Ying Choon Wu, Ping Zheng, Xiaojun Wang, Ping Bie, Fengtian He, Leida Zhang, Chuanming Xie
| Nature Verified
Abstract D-type cyclins (hereafter, cyclin D) are central regulators orchestrating G1/S cell cycle transition. Accordingly, aberrant expression of cyclin D is strongly correlated with proliferation-related diseases such as cancer. However, the mechanisms regulating cyclin D turnover are incompletely elucidated. Here we identify FBXO32, namely atrogin-1, as the E3 ubiquitin ligase that targets all three cyclin D for ubiquitination and stabilization.
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