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Deacetylation of ANXA2 by SIRT2 desensitizes hepatocellular carcinoma cells to donafenib via promoting protective autophagy - Cell Death & Differentiation
Abstract Hepatocellular carcinoma (HCC) is one of the most lethal forms of cancer globally. HCC cells frequently undergo macroautophagy, also known as autophagy, which can lead to tumor progression and chemotherapy resistance. Annexin A2 (ANXA2) has been identified as a potential therapeutic target in HCC and is involved in the regulation of autophagic process. Here, we for the first time showed that ANXA2 deacetylation plays a crucial role in donafenib-induced autophagy.
Recent Progress in Microenvironment‐Responsive Nanodrug Delivery Systems for the Targeted Treatment of Rheumatoid Arthritis
Conflicts of Interest The authors declare no conflicts of interest. References , , , et al. 2017. “Endogenous Inspired Biomineral-Installed Hyaluronan Nanoparticles as pH-Responsive Carrier of Methotrexate for Rheumatoid Arthritis.” Journal of Controlled Release 252: 62–72. https://doi.org/10.1016/j.jconrel.2017.03.012. , , , et al. 2016. “Acid-Sensitive Sheddable PEGylated PLGA Nanoparticles Increase the Delivery of TNF-α siRNA in Chronic Inflammation Sites.” Molecular Therapy – Nucleic Acids 5: e340.
Risk factors for penetrating aortic ulcer progression
KEYWORDS penetrating aortic ulcer penetrating atherosclerotic ulcer antineoplastic agents acute aortic syndrome aortic intramural hematoma Get full text access Log in, subscribe or purchase for full access. References 1. Riambau, V. ∙ Böckler, D. ∙ Brunkwall, J. ... Editor's Choice - Management of Descending Thoracic Aorta Diseases: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS) Eur J Vasc Endovasc Surg. 2017; 53:4-52 2. Tittle, S.L. ∙ Lynch, R.J. ∙ Cole, P.E. ...
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