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Feodor D. Price on Muck Rack

Feodor D. Price

As seen in: Nature, Cell Reports
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Articles

Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration - Nature Biotechnology

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By Feodor D. Price, William Chen, Pooja S. Singu, James M. Poteracki, Kelsey Goune, Isabella Pfeiffer, Sarah A. Boswell, Peter K. Sorger, Emanuela Gussoni
| Nature Verified
Abstract Experimental cell therapies for skeletal muscle conditions have shown little success, primarily because they use committed myogenic progenitors rather than true muscle stem cells, known as satellite cells. Here we present a method to generate in vitro-derived satellite cells (idSCs) from skeletal muscle tissue.
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FOS licenses early events in stem cell activation driving skeletal muscle regeneration

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By Albert E. Almada, Alfredo Gonzalez, Naftali Horwitz, Feodor D. Price
| Cell Reports Verified
Highlights • Injury-exposed satellite cells (SCs) rapidly and transiently induce FOS • FOS-expressing SCs activate faster and display superior regenerative activity • Fos-null SCs activate more slowly and have diminished regenerative activity • The FOS target Art1 is required for efficient SC activation and muscle repair Summary Muscle satellite cells (SCs) are a quiescent (non-proliferative) stem cell population in uninjured skeletal muscle.
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