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Highlights • ppGpp was directly tuned outside of native concentrations with a synthetic system • Cell size inversely correlates with ppGpp concentration, not with growth rate • ppGpp shifts can change cell division timing within a single cell cycle • ppGpp can regulate cell size directly—not by modulating the growth rate Summary Growth and division are central to cell size.
Research Article | Molecular Biology and Physiology Marek J. Noga, Ferhat Büke, Niels J. F. van den Broek, Nicole C. E. Imholz, Nicole Scherer, Flora Yang, Gregory Bokinsky M. Stephen Trent, Editor DOI: 10.1128/mBio.02703-19 ABSTRACT Every cell must produce enough membrane to contain itself. However, the mechanisms by which the rate of membrane synthesis is coupled with the rate of cell growth remain unresolved.
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