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Fern Barrington on Muck Rack

Fern Barrington

As seen in: Science Magazine, BioRxiv, eLife
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Articles

The insulin/IGF axis is critically important for controlling gene transcription in the podocyte

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By Jenny A. Hurcombe, Lusyan Dayalan, Fern Barrington
| eLife
eLife Assessment This valuable study used genetic and pharmacological manipulations of insulin/IGF signaling to address the role of insulin/IGF axis in the function of renal glomerular podocyte. Solid data are presented to demonstrate that co-inhibition of insulin/IGF signaling in podocytes led to aberrant splicing of mRNAs, which could contribute to the loss of podocytes in vitro and in vivo in mice.
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The insulin / IGF axis is critically important controlling gene transcription in the podocyte.

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By Jennifer A. Hurcombe, Fern Barrington, Frédéric Burdet, Lusyan Dayalan
| BioRxiv
Abstract Signalling to the podocyte via the structurally related insulin receptor (IR) or insulin-like growth factor 1 receptor (IGF1) is important for podocyte function. This study sought to elucidate the compound role of the insulin/IGF1 axis in podocytes using transgenic mice and cell culture models deficient in both receptors.
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