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Fernandes Dde

As seen in: British Journal of Cancer
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Articles

Vitamin E δ-tocotrienol triggers endoplasmic reticulum stress-mediated apoptosis in human melanoma cells

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By Daniel Tan, Fred Wong, Fernandes Dde, Montagnani Marelli
| British Journal of Cancer Verified
BLM and A375 cells, or normal human melanocytes, were treated with δ-TT (5–20 μg/ml) for 24 h or 48 h; cell viability was assessed by MTT assay. Figure 1a shows that the tocotrienol dose-dependently inhibited the number of viable melanoma cells at both time intervals, being significantly effective at 10–20 μg/ml (Fig. 1a). These doses correspond to those previously reported for the antitumor activity of tocotrienols in cancer cell lines33,34,35.
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