Fitzwilliam Seibertz on Muck Rack

Fitzwilliam Seibertz

As seen in: Nature, Oxford University Press (OUP)
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Articles

A modular method for high-throughput measurement of ion channel currents in cardiac myocytes

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By Fitzwilliam Seibertz, Alexey Alekseev, Thomas Mager, Constanze Schmidt, Niels Voigt, Izzatulo Sobitov, Marcus L. Gerloff, Aiste Liutkute, Funsho E. Fakuade
| Nature Verified
Abstract The patch-clamp technique offers unparalleled insight into the electrical and biophysical behavior of excitable cells. However, it is a slow and low-throughput method that typically requires cells to be measured one by one. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are regularly subjected to this technique to unravel the molecular mechanisms of cardiac diseases.
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Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy - Nature Cardiovascular Research

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By Eirini Kyriakopoulou, Fitzwilliam Seibertz, Mauro Giacca, Hoyee Tsui, Niels Voigt
| Nature Verified
Abstract Arrhythmogenic cardiomyopathy is a severe cardiac disorder characterized by lethal arrhythmias and sudden cardiac death, with currently no effective treatment. Plakophilin 2 (PKP2) is the most frequently affected gene.
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Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development

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By Georg-August-University Göttingen, Tony Rubio, Díaz i Pedrosa, Fitzwilliam Seibertz
| Oxford University Press (OUP)
Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology alterations which promote AF chronification and treatment resistance. Development of novel antiarrhythmic therapies is hampered by the absence of scalable experimental human models that reflect AF-associated electrical remodelling.
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