Articles by Flora Yang
Frequency of germline pathogenic variants in breast cancer predisposing genes in a national cohort of young women with breast cancer
Abstract The objective of the study was to evaluate the prevalence of pathogenic variants in 18 cancer predisposition genes in a national cohort of women with breast cancer diagnosed at age 40 or younger. Women with breast cancer at age ≤40 years were recruited from 33 Canadian centres at diagnosis. Germline genetic testing was performed for 18 genes (ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, PALB2, PTEN, STK11, RAD51D, RAD51C, EPCAM, MLH1, MSH2, MSH6, and PMS2).
Exogenous fatty acids inhibit fatty acid synthesis by competing with endogenously generated substrates for phospholipid synthesis in Escherichia coli
Abbreviations ACC, acetyl-CoA carboxylase ACP, acyl carrier protein LCMS, liquid chromatography coupled with mass spectrometry LPA, lysophosphatidic acid MOPS, 3-(morpholine-4-yl)propane-1-sulfonic acid PA, phosphatidic acid PE, phosphatidylethanolamine PG, phosphatidylglycerol ppGpp, guanosine tetraphosphate PS, phosphatidylserine The synthesis of lipids for membrane biogenesis consumes considerable amounts of energy and metabolites.
Exogenous fatty acids inhibit fatty acid synthesis through competition between endogenously- and exogenously-generated substrates for phospholipid synthesis in Escherichia coli
Abstract Exogenous fatty acids are directly incorporated into bacterial membranes, heavily influencing bacterial ecology and antibiotic susceptibility. We use liquid chromatography/mass spectrometry to characterize how exogenous fatty acids impact the Escherichia coli fatty acid synthesis pathway. We find that acyl-CoA synthesized from exogenous fatty acids rapidly increases long-chain acyl-ACP levels while depleting malonyl-ACP, indicating inhibition of fatty acid synthesis.
A temperature-sensitive metabolic valve and a transcriptional feedback loop drive rapid homeoviscous adaptation in Escherichia coli
Abstract All free-living microorganisms homeostatically maintain the fluidity of their membranes by adapting lipid composition to environmental temperatures. A quantitative description of how organisms maintain constant fluidity at all growth temperatures has not been achieved. By quantifying both enzymes and metabolic intermediates of the Escherichia coli fatty acid and phospholipid synthesis pathways, we discover how E.
Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli
Research Article | Molecular Biology and Physiology Marek J. Noga, Ferhat Büke, Niels J. F. van den Broek, Nicole C. E. Imholz, Nicole Scherer, Flora Yang, Gregory Bokinsky M. Stephen Trent, Editor DOI: 10.1128/mBio.02703-19 ABSTRACT Every cell must produce enough membrane to contain itself. However, the mechanisms by which the rate of membrane synthesis is coupled with the rate of cell growth remain unresolved.
Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures
Citation: Srinivasan P, Moss JA, Gunawardana M, Churchman SA, Yang F, Dinh CT, et al. (2016) Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures. PLoS ONE 11(6): e0157061. doi:10.1371/journal.pone.0157061 This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
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