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Pediatric Craniofacial Osteosarcoma: The Milano Experience
1 Introduction Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents and young adults and mostly affects the long bones of the extremities [1]. On the contrary, only 4%–8% of the OSs arise in craniofacial structures and skull, more frequently in older patients, usually over 60 years old [2-5]. Therefore, craniofacial osteosarcomas (CFOSs) are truly rare in pediatric patients.
Association of Immune-Related Adverse Events With the Outcomes of Immune Checkpoint Inhibitors in Patients With dMMR/Msi-H Metastatic Colorectal Cancer
BACKGROUND: Immune checkpoint inhibitors (ICIs) show a tremendous activity in microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC), but a consistent fraction of patients does not respond. Prognostic/predictive markers are needed.
Extent of macroscopic vascular invasion predicts distant metastasis in primary leiomyosarcoma of the inferior vena cava
CONFLICT OF INTEREST STATEMENT Dr. Silvia Stacchiotti—honoraria, consultancy or advisory role: Aadi, Agenus, Astex Pharmaceuticals, Bavarian Nordic, Bayer, Boehringer, Daiichi Sankyo, Gentili, Glaxo, Ikena, NEC oncoimmunity, Novartis, Pharmamar, Pharma Essentia, Rain Therapeutics, Regenron, Servier.
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