Francesco Mannara on Muck Rack

Francesco Mannara

Barcelona
As seen in: Wiley, Cell Press, Neurology
PhD Student in Biomedicne at the University Barcelona
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Articles

Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice

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By Marija Radosevic, Jesús Planagumà, Francesco Mannara, Araceli Mellado
| Neurology Verified
Abstract Background and Objectives To demonstrate that an analog (SGE-301) of a brain-derived cholesterol metabolite, 24(S)-hydroxycholesterol, which is a selective positive allosteric modulator (PAM) of NMDA receptors (NMDARs), is able to reverse the memory and synaptic alterations caused by CSF from patients with anti-NMDAR encephalitis in an animal model of passive transfer of antibodies.
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NMDAr antibodies alter dopamine receptors and cause psychotic behavior in mice

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By Francesco Mannara, Esther Aguilar, Aida Castellanos, Marc Carceles‐Cordon
| Wiley
Research Article Josep Dalmau MD, PhD Corresponding Author E-mail address: jdalmau@clinic.cat Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain Department of Neurology, University of Pennsylvania, Philadelphia, US Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain These authors have equally contributed as seniors authors.Address correspondence to Josep Dalmau, MD, PhD, IDIBAPS‐Hospital...
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Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction

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By Universitat de Barcelona, Christian Werner, Holger Haselmann, Francesco Mannara
| Cell Press Verified
AMPA receptors are essential for fast excitatory transmission in the CNS. Autoantibodies to AMPA receptors have been identified in humans with autoimmune encephalitis and severe defects of hippocampal function.
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