Francesco Massimo Perla on Muck Rack

Francesco Massimo Perla

As seen in: The Journal of Pediatrics, Atherosclerosis
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Articles

Upregulated monocyte expression of PLIN2 is associated with early arterial injury in children with overweight/obesity

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By Lúcia Pacífico, Francesco Massimo Perla, Giovanna Liuzzo, Eugenia Pisano
| Atherosclerosis Verified
Highlights • Lipid droplets Plin2 protein is overexpressed in monocytes of children with obesity. • Early arterial injury in children with obesity is associated with increased Plin2 protein expression in monocytes. • Plin2 upregulation could depend on proteasome impairment in children with obesity. Abstract Background and aims Perilipin 2 (PLIN2) regulates intracellular lipid metabolism in macrophages, and thus, plays a role in atherosclerosis.
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Elevated Serum Concentrations of Remnant Cholesterol Associate with Increased Carotid Intima-Media Thickness in Children and Adolescents

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By Alessia di Costanzo, Francesco Massimo Perla, Laura D’Erasmo, Claudio Chiesa
| The Journal of Pediatrics Verified
Objective To evaluate the relationship between remnant cholesterol and carotid intima-media thickness (cIMT), a surrogate marker for atherosclerosis, in children and adolescents. Study design Anthropometric, laboratory, liver and carotid ultrasonographic data were obtained from 767 youths (594, overweight/obese; 173, normal weight). Fasting RC was calculated from the standard lipid profile.
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