Francis Crick Ave

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease.

Highlights • Yor1-ΔF shows synthesis defects when Sec61 or EMC function is compromised • Synthesis defects are suppressed by ribosomal and RQC mutants • Translation initiation is a second point of potential regulation • Pre-emptive quality control on the ER might protect the cell from aberrant proteins Summary Cells possess multiple mechanisms that protect against the accumulation of toxic aggregation-prone proteins.

a Department of Chemistry, University of Pittsburgh, 219 Parkman Ave, Pittsburgh, USA E-mail: deiters@pitt.edu b Medical Research Council Laboratory of Molecular Biology, Francis Crick Ave, Cambridge CB20QH, UK c Department of Chemistry and The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel d Department of Chemistry, North Carolina State University, Raleigh, USA