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Francis Freenor V on Muck Rack

Francis Freenor V

As seen in: The Journal of Biological Chemistry
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Articles

An evolutionary T119R substitution in the macaque T-cell immunoreceptor TIGIT enables proteolytic shedding and reveals clinical antibody vulnerabilities

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By Sanchita Bhatnagar, Eric Pirillo, Francis Freenor V, Brice E.N. Wamba
| The Journal of Biological Chemistry Verified
Introduction CD155 belongs to the Ig-superfamily (IgSF) and interacts with other IgSF immune receptors on lymphocytes to produce either activating or inhibitory outcomes. The low-affinity CD155-CD226 interactions promote anti-tumor immune activation, while the high-affinity (<0.1nM) CD155-TIGIT interactions are immune-inhibitory(1). Considering CD155 levels are significantly elevated in various solid tumor types(2), TIGIT remains a significant immune checkpoint receptor (ICR).
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