Francisco Monge Neria on Muck Rack

Francisco Monge Neria

As seen in: Cell Press
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DNA Helicase Mph1FANCM Ensures Meiotic Recombination between Parental Chromosomes by Dissociating Precocious Displacement Loops

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By Rima Sandhu, Xiangyu Chen, Francisco Monge Neria, Jesús Monge Neria
| Cell Press Verified
Highlights • Meiotic double-strand breaks form D-loops following pairing of parental chromosomes • DNA helicase Mph1FANCM dissociates precocious D-loops between sister chromatids • Intersister repair due to lack of Mph1 triggers a non-crossover-to-crossover shift • Synapsis protein Zip1 protects D-loops between parental chromosomes from Mph1 Summary Meiotic pairing between parental chromosomes (homologs) is required for formation of haploid gametes.
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