Fraser Todd Sparks on Muck Rack

Fraser Todd Sparks

As seen in: Cell Press
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Articles

Normal CA1 Place Fields but Discoordinated Network Discharge in a Fmr1-Null Mouse Model of Fragile X Syndrome

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By Bridget Curran, Zoe Nicole Talbot, Fraser Todd Sparks, Dino Dvorak
| Cell Press Verified
Silence of FMR1 causes loss of fragile X mental retardation protein (FMRP) and dysregulated translation at synapses, resulting in the intellectual disability and autistic symptoms of fragile X syndrome (FXS). Synaptic dysfunction hypotheses for how intellectual disabilities like cognitive inflexibility arise in FXS predict impaired neural coding in the absence of FMRP. We tested the prediction by comparing hippocampus place cells in wild-type and FXS-model mice.
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