Fudo Satoshi on Muck Rack

Fudo Satoshi

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Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition - Nature Communications

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By Xavier Prasanna, Helena Vihinen, Yinglan Zhao, Eija Jokitalo, Ilpo Vattulainen, Tommi A. Kajander, Hongxia Zhao, Fudo Satoshi
| Nature Verified
Abstract The Bin/Amphiphysin/Rvs (BAR) domain protein FAM92A1 is a multifunctional protein engaged in regulating mitochondrial ultrastructure and ciliogenesis, but its physiological role in the brain remains unclear. Here, we show that FAM92A1 is expressed in neurons starting from embryonic development. FAM92A1 knockout in mice results in altered brain morphology and age-associated cognitive deficits, potentially due to neuronal degeneration and disrupted synaptic plasticity.
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