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Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition - Nature Communications
Abstract The Bin/Amphiphysin/Rvs (BAR) domain protein FAM92A1 is a multifunctional protein engaged in regulating mitochondrial ultrastructure and ciliogenesis, but its physiological role in the brain remains unclear. Here, we show that FAM92A1 is expressed in neurons starting from embryonic development. FAM92A1 knockout in mice results in altered brain morphology and age-associated cognitive deficits, potentially due to neuronal degeneration and disrupted synaptic plasticity.
Land Finance, Local Government Debt and Economic Green Transformation
1. Introduction From the inception of the United Nations Framework Convention on Climate Change to the ratification of the Kyoto Protocol and the Copenhagen Climate Conference, environmental concerns, particularly those related to global warming caused by carbon emissions and particulate matter emissions, have garnered increasing global attention.
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