Fumiyoshi Ishidate on Muck Rack

Fumiyoshi Ishidate

As seen in: Nature, Cell Press
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Articles

Confined migration induces non-lethal DNA damage in developing neurons

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By Zhejing Zhang, Andres Canela, Junko Kurisu, Peilin Zou, Takumi Kawaue, Naotaka Nakazawa, Noriko Takeda, Merve Bilgic, Fumiyoshi Ishidate, Gianluca Grenci, Takahiro Furuta, Yusuke Kishi, Hiroyuki Sasanuma, Mineko Kengaku, Mai Saeki, Masaki Utsunomiya
| Nature Verified
Abstract Migratory cells tend to have soft nuclei that deform and penetrate narrow spaces1,2. Extensive nuclear deformation during migration can cause nuclear-envelope rupture and DNA damage in cancer cells, which may contribute to malignant transformation during tumour progression3,4,5,6. However, the importance of DNA damage in physiological migration is less well understood.
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All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds

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By Kengo Nomura, Kyoto Prefectural, Miho Nakanishi, Fumiyoshi Ishidate
| Cell Press Verified
Highlights • ENaC + CALHM1/3 + taste cells are sodium cells dedicated to attractive sodium taste • Sodium cells fire action potentials in response to ENaC-mediated Na + influx • CALHM1/3 channels mediate purinergic neurotransmission of sodium taste • Sodium taste transduction completely bypasses intracellular Ca 2+ signals Summary Sodium taste regulates salt intake. The amiloride-sensitive epithelial sodium channel (ENaC) is the Na + sensor in taste cells mediating attraction to sodium salts.
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