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FuNien Tsai

As seen in: BioRxiv
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Articles

Live-cell transcriptomics with engineered virus-like particles

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By Mohamad Ali Najia, Jacob Borrajo, Anna Le, FuNien Tsai
| BioRxiv
Abstract The transcriptional state of a cell provides a multi-parameter representation of gene expression programs that reflect its identity and phenotype. However, current transcriptomic profiling technologies result in destruction of the biological sample, preventing direct analysis of transcriptional dynamics in the same living cells over time. Here, we developed a synthetic RNA export system called cellular 'self-reporting' to address this fundamental technological limitation.
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