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Gabriele Partel

As seen in: Nature, BioRxiv
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Articles

Axonal Eif5a hypusination controls local translation and mitigates defects in FUS-ALS - Nature Neuroscience

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By Diana Piol, Bilal Khalil, Gabriele Partel, David Wouters, Nikky Corthout, Sam Kint, Katy Vandereyken, Philip Van Damme, Thierry Voet, Kristofer Davie, Stein Aerts
| Nature Verified
Abstract Local protein synthesis is vital for neuronal function, but its dysregulation in neurodegenerative diseases remains poorly defined. Here we applied spatial transcriptomics to adult mouse motor nerve axons and cell bodies to enable subcellular mapping.
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Spatial transcriptomics in adult Drosophila reveals new cell types in the brain and identifies subcellular mRNA patterns in muscles

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By Jasper Janssens, Pierre Mangeol, Nikolai Hecker, Gabriele Partel
| BioRxiv
Abstract Recently, we have achieved a significant milestone with the creation of the Fly Cell Atlas. This single-nuclei atlas encompasses the entire fly, covering the entire head and body, in addition to all major organs. This atlas catalogs hundreds to thousands of cell types, of which we annotated 250. This still leaves many clusters to be fully characterized, in particular in the brain.
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Identification of spatial compartments in tissue from in situ sequencing data

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By Gabriele Partel, Markus M. Hilscher, Giorgia Milli, Leslie Solorzano
| BioRxiv
Abstract Spatial organization of tissue characterizes biological function, and spatially resolved gene expression has the power to reveal variations of features with high resolution. Here, we propose a novel graph-based in situ sequencing decoding approach that improves recall, enabling precise spatial gene expression analysis.
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