Gaeun Lee

1 Introduction Alzheimer's disease (AD) is the most common form of dementia and a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain [1]. While the majority of AD cases are sporadic and occur later in life, genetic risk factors play a critical role in disease susceptibility and progression [2].

1 Introduction Glioblastoma (GBM) is the most prevalent and aggressive type of brain cancer, with a median survival of less than 15 months despite multimodal therapy [1, 2]. The poor prognosis of GBM is primarily due to its intrinsic heterogeneity across patients and diffusively infiltrative growth pattern, which hinders complete surgical resection and facilitates recurrence [3, 4].

Also available on ScienceDirect