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Gamze Bölükbaşı Ateş

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Articles

Iron deficiency induces maturation-dependent loss of pancreatic β-cells - Nature Communications

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By Annelore Van Mulders, Sophie Coenen, Stephanie Bourgeois, Xiaoyan Yi, Yue Tong, Gunter Leuckx, Yves Heremans, Julie Pierreux, Toshiaki Sawatani, Chiara Vinci, Gamze Bölükbaşı Ateş, Ann MacLean Massie, Françoise Carlotti, Eelco de Koning, Thomas Mandrup-Poulsen, Steven Goderis, Bart Ghesquière, Raphaël Scharfmann, Miriam Cnop, Willem Staels, Lien Willems, Laure Degroote, Clara Zelinsky, Nico De Leu
| Nature Verified
Abstract Pancreatic β-cells maintain glucose homeostasis by secreting insulin in response to rising blood glucose, a process fueled by mitochondrial ATP production. Iron, a core cofactor in the electron transport chain, is essential for this metabolic coupling. While the cytotoxic effects of iron overload are well known, the role of iron sufficiency during β-cell development remains unclear. Here, we identify a maturation-dependent requirement for iron in mouse and human β-cells.
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Intact corticostriatal function in aged system xc- - deficient mice - Translational Psychiatry

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By Lutgarde Arckens, Laurence Ris, Gamze Bölükbaşı Ateş, Agnès Villers, Olaya Lara
| Nature Verified
Abstract System xc- (with xCT as specific subunit) is an astrocytic cystine/glutamate antiporter that constitutes the major source of extracellular glutamate in the mouse striatum. We previously reported that young-adult mice lacking xCT (xCT-/- mice) display decreased intracellular glutamate levels in pre- and post-synaptic compartments at corticostriatal synapses as well as impaired corticostriatal neurotransmission, compared to wildtype (xCT+/+) littermates.
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AMPKα1 Deficiency in Astrocytes from a Rat Model of ALS Is Associated with an Altered Metabolic Resilience

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By Gamze Bölükbaşı Ateş, Pauline Beckers, Ann MacLean Massie, Nathalie Desmet
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
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