Gangning Liang

1. Introduction Vpr binding protein (VprBP) was initially identified as the cellular target and binding protein of the human immunodeficiency virus type 1 (HIV-1) accessory protein viral protein r (Vpr) and also named DDB1- and CUL4-associated factor1 (DCAF1) [1].

This is a preprint. It has not yet been peer reviewed by a journal. The National Library of Medicine is running a pilot to include preprints that result from research funded by NIH in PMC and PubMed. Display options Abstract Background Melanoma is the most aggressive form of skin cancer arising from pigment-producing melanocytes and is often associated with dysregulation of epigenetic factors targeting histones.

This is a preprint. It has not yet been peer reviewed by a journal. The National Library of Medicine is running a pilot to include preprints that result from research funded by NIH in PMC and PubMed. Display options Abstract DCAF1, also known as VprBP, is a recently identified atypical kinase and plays an important role in downregulating the transcription of tumor suppressor genes as well as increasing the risk for colon and prostate cancers.