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Articles by Gareth Wright
Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila
Abstract Excessive foraging of colonic mucin glycans by gut bacteria is associated with diseases such as inflammatory bowel disease. Although Akkermansia muciniphila is an important mucin degrader, the role of carbohydrate sulfatases that facilitate digestion of these heavily sulfated glycans remains unclear. Combining in vitro digestion assays, proteomics and structural biology, we show that A.
Mediterranean’s AI momentum surges as GITEX launches in Italy’s US$92B digital economy
Trixie LohMirmand, CEO of GITEX with Francesco Marcolini, President of Lazio Innova Official signing ceremony for the announcement of GITEX AI Mediterranean Italy The inaugural GITEX AI Mediterranean Italy will take place from 21-22 April 2027 in Rome GITEX AI Mediterranean/Italy April 2027 in Rome catalyses global tech ecosystem expansion across the Mediterranean’s ascending intelligence economy Through GITEX AI Mediterranean/Italy, we are creating a strategic nexus that channels this force...
Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection
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Abstract The paraspeckle is a disease-relevant biomolecular condensate assembled from long non-coding RNA (lncRNA) NEAT1_2 ribonucleoprotein particles. Paraspeckle biogenesis is suppressed in normal tissues, yet it can be rapidly upregulated under stress.
By Rachel Hodgson, Wan-Ping Huang, Vedanth Kumar, Haiyan An, Mark Driver, Anna Sanchez Avila, Brittany Ellis, Emily Day, Jessica Rayment, Kyungmin Baeg, Andrew Strange, Tobias Moll, Gareth Wright, Joke van Vugt, Scott Allen, Nicolas Locker, Ianthe L. Pitout, Susan Fletcher, Patrick R. Onck, Olivier Duss, Johnathan Cooper-Knock, Tatyana A. Shelkovnikova, Ruaridh Lang, Emil G. P. Stender, Zhaklin P. Chalakova
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Nature
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OPINION: NHS waiting lists in Cambridgeshire hit record high with no sign of improvement
NHS waiting lists have hit a record high in Cambridgeshire, with the latest figures for Cambridge University Hospitals NHS Foundation Trust (which runs Addenbrooke’s Hospital and the Rosie Hospital) showing that 62,964 people are waiting to start treatment. The national standard for patients to start treatment within 18 weeks is 92%. This target is being missed across the NHS. Here in Cambridgeshire, just 56% of patients start treatment within 18 weeks. I work at Addenbrooke’s hospital.
LETTER: ‘Those responsible for what happened must be held to account’
The Covid inquiry continues to drip feed the details of how the government dealt with the Coronavirus pandemic. I work in the NHS, and I witnessed the horrors of the pandemic from the frontline. Hearing from the inquiry about the levels of callousness and incompetence is hard to cope with. I will not forget the terror in the eyes of those gasping for air as they came through the doors, ubiquitously repeating the phrase ‘I can’t breathe’.
OPINION: ‘Sticking plaster policies will not help those in need’
This week in parliament the health secretary Steve Barclay announced his emergency care recovery plan. Amongst the measures in his statement, he triumphantly announced a desire to see category two ambulance response times, those covering strokes and heart attacks, down to 30 minutes by March next year. This is almost double the current target for these patients which stands at 18 minutes.
Nom Nom Galaxy crash-lands on PS4 next week
Pick up the latest from Q Games and Double Eleven from 12th May Hi everyone.
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