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Articles

Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases

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By Byunghee Koh, Ryota Sato, HUNG NGUYEN, Garrett Dunlap, Christopher B. Mahony, Chrissy Bolton, Lucy R Wedderburn, Adam Croft, Laura T. Donlin, Melanie Smith, Soumya Raychaudhuri, Ilya Korsunsky, Deepak Rao, Michael Brenner, Shani T. Gal Oz
| Nature Verified
Abstract Regulatory T cells (Treg cells), characterized by FOXP3 expression, maintain immune homeostasis, but their function is impaired in autoimmune diseases such as rheumatoid arthritis (RA). Here we used single-cell RNA sequencing to analyze Treg cells in synovial tissues from patients with RA. We identified two predominant Treg states, CD25hiCXCR6pos Treg cells and dysfunctional CD25loAREGpos Treg cells, both enriched in synovial tissues but not in blood.
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