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Articles by Gary Ruvkun
Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans.
Abstract Detecting and responding to pathogenic bacteria is an essential function of eukaryotic cells. As bacteria-derived organelles, mitochondria carry lipids, proteins, and other molecules such as iron which are required for bacterial growth, and thus are subject to pathogenic bacterial attack. In fact, mitochondrial morphology and function are often altered during early bacterial infection. However, the mechanism by which bacterial pathogen attack triggers mitochondrial responses is unknown.
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency - Nature
Abstract Frataxin is a key component of an ancient, mitochondrial iron–sulfur cluster biosynthetic machinery, serving as an allosteric activator of the cysteine desulfurase NFS1 (refs. 1,2,3,4,5). Loss of frataxin levels underlies Friedreich’s ataxia6, the most common inherited ataxia. Yeast, Caenorhabditis elegans and human cells can tolerate loss of frataxin when grown in ‘permissive’ low oxygen tensions7. Here we conducted an unbiased, genome-scale forward genetic screen in C.
Five UC-affiliated scientists win 2024 Nobel Prizes
The Nobel committee announced its final prize in economics on Monday, Oct. 14. Of the 12 winners of 2024 prizes, five have deep UC ties. Spanning the fields of medicine, physics, chemistry and economics, they all spent significant time at the University of California, as students, researchers or faculty, benefitting from the university’s living legacy of groundbreaking research, including mentorship from Nobel Prize-winning colleagues.
Four UC-affiliated scientists win 2024 Nobel Prizes
The Nobel committee will announce its final prize in Economics on Monday, Oct. 14. But of the eight winners so far, four have deep UC ties. Spanning the fields of medicine, physics and chemistry, they all spent significant time at the University of California, as students, researchers or faculty, benefitting from the university’s living legacy of groundbreaking research, including mentorship from Nobel Prize-winning colleagues.
CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene
Highlights • cmtr-1 G-patch mutations activate broad expression of a neuronal complex I subunit • NDUFS2/nduf-2.2 is normally restricted to the dopaminergic neurons in C. elegans • G-patch loss causes ectopic localization of CMTR-1 protein to processing bodies • Mutations in the mRNA binding protein Serrate phenocopy CMTR-1 G-patch mutations Summary 1 Rath S. Sharma R. Gupta R. Ast T. Chan C. Durham T.J. Goodman R.P. Grabarek Z. Haas M.E. Hung W.H.W. et al.
Perturbed sulfur homeostasis allows C. elegans to escape growth retardation on Actinobacteria from its natural microbiome
Abstract The rate at which organisms grow is influenced by their biotic environment. The nematode Caenorhabditis elegans grows slower in the presence of Actinobacteria, but it is unknown why. Here, we show how perturbed levels of hydrogen sulfide and cysteine modulate the growth rate of C. elegans on Actinobacteria. Using an unbiased forward genetic screen of C. elegans we discovered alleles of the conserved cystathionine gamma-lyase (cth-2/CTH) that improved animal growth rate on Actinobacteria.
Hypoxia-inducible factor promotes cysteine homeostasis in Caenorhabditis elegans
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Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response
Loading metrics Open Access Peer-reviewed Research Article Kai Mao, Peter Breen, Gary Ruvkun Kai Mao, Peter Breen, Gary Ruvkun Published: December 2, 2020 https://doi.org/10.1371/journal.pbio.3000996 ? This is an uncorrected proof. Figures Abstract RNA interference (RNAi) is an antiviral pathway common to many eukaryotes that detects and cleaves foreign nucleic acids.
Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism
Models to predict six life outcomes based on data collected over 15 years suggest that the use of predictive models in criminal and social systems may need to be reevaluated, along with the assumption that life trajectories can be predicted.
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons Sylvia E. J. Fischer, Gary Ruvkun Proceedings of the National Academy of Sciences Mar 2020, 201919028; DOI: 10.1073/pnas.1919028117
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
Highlights • PNGase edits glycosylated Asn residues of the SKN-1A transcription factor to Asp • These edits are required for SKN-1A to regulate proteasome subunit genes • Sequence-edited SKN-1A enhances proteostasis • Edits cause ER-targeted and cytosolic SKN-1 isoforms to regulate distinct genes Summary The proteasome mediates selective protein degradation and is dynamically regulated in response to proteotoxic challenges.
CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing
CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing Angel Mojarro, Julie Hachey, Gary Ruvkun, Maria T. Zuber, Christopher E. Carr bioRxiv 175281; doi: https://doi.org/10.1101/175281
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