Geehoon Chung

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description glia70110-sup-0001-VideoS1.aviAVI video, 73 MB Video S1: Awake two-photon calcium imaging of astrocytes.

Open AccessArticle by Nari Kim 1,†, Geehoon Chung 2,†, So-Ri Son 3,†, Jae Hyun Park 4, Young Hyun Lee 1,5, Keon-Tae Park 3, Ik-Hyun Cho 1,5, Dae Sik Jang 3,* and Sun Kwang Kim 1,2,4,* 1 Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea 2 Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea 3 Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee...

Highlights • Activation of mGluR5 in PAG neurons modulates pain • Normally, PAG-mGluR5 is persistently active to regulate neuronal excitability • In neuropathic pain, PAG-mGluR5 activity is inhibited by Homer1a expression • Inactivation of PAG-mGluR5 induces and maintains neuropathic pain symptoms Summary Pain sensation is powerfully modulated by signal processing in the brain, and pain becomes chronic with the dysfunction of the pain modulatory system; however, the underlying mechanisms are...