Children with medical complexity (CMC)—a vulnerable population with multiple chronic conditions, functional limitations, and health services utilization1,2—have a high risk of COVID-19 morbidity and mortality.3 Regular access to in-home COVID-19 rapid antigen testing could be a valuable component of long-term pandemic management and may improve CMC’s health by facilitating earlier detection and symptom monitoring, implementation of clinical action plans (e.g., for respiratory illness), and...