Gencer Sancar on Muck Rack

Gencer Sancar

As seen in: Frontiers, Cell Metabolism
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Articles

Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor

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By Klinikum St. Georg, Gencer Sancar, Siresha Bathina
| Frontiers
Introduction Chronic kidney disease (CKD) has a leading global health impact and is a multisystem disease state accounting for about 1.2 million deaths per year worldwide (1). Key pathomechanisms include a proinflammatory status, increased oxidative stress and cellular senescence (2, 3), thereby contributing to increased mortality with about 40-50% of deaths attributed to cardiovascular diseases (4).
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FGF1 and insulin control lipolysis by convergent pathways

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By Gencer Sancar, Sihao Liu, Emanuel Gasser
| Cell Metabolism Verified
Highlights • FGF1-FGFR1 signaling suppresses adipose lipolysis to curb hepatic glucose production • FGF1 suppresses lipolysis by inhibiting cAMP/PKA axis via PDE4D-S44 phosphorylation • Overexpression of PDE4D in the adipose tissue of diabetic mice corrects hyperglycemia • FGF1/PDE4D antilipolytic pathway is responsive to fed/fast states Summary Inexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP) are hallmarks of type 2 diabetes.
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