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Articles by Gengxi Lu
Air-permeable hydrogels through viscoelastic phase separation of aerogels
Abstract Hydrogels are widely used in biomedical interfaces, in which effective gas exchange (for example, O2, CO2) within a water-rich environment is essential. However, hydrogels show intrinsically limited air exchange efficiency, owing to the low solubility (C) and diffusivity (D) of non-polar gases in the polar water medium1. This limitation poses a substantial bottleneck in long-term applications, such as wearable health monitors2,3,4,5,6,7 and tissue engineering8,9,10,11,12.
A wearable non-invasive sonogenetic pacemaker
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Abstract Cardiac pacemakers are critical for treating heart rhythm disorders, but traditional implants are associated with great risks and complications owing to their invasive nature. Here we introduce a wearable non-invasive ultrasound pacemaker (NUP) that activates engineered sonogenetic ion channels (MscL-G22S) to modulate cardiomyocytes, achieving spatiotemporally controlled precise cardiac pacing.
By Chen Gong, Gengxi Lu, Baoqiang Liu, Jie Ji, fan wei, Junhao Lin, Xiao Qing Wan, Songsong Tang, Runze Li, Fengyi Ma, Jaemin Seo, Sunyoung Jung, Jiawen Chen, ShanShan Wang, Shanshan Wang, Junhang Zhang, Xin Sun, Jiarui Wang, Yushun Zeng, Gengle Niu, Xinhao Yang, Xunan Liu, Joshua I. Chalif, Shucong Li, Hsiao-Chuan Liu, Longwei Liu, Hangbo Zhao, jun chen, Yingxiao Wang, Xuanhe Zhao, Qifa Zhou, Z. Phil Che, Christoph G. S. Nabzdyk
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Nature
Verified
Hand tracking using wearable wrist imaging
Abstract The human hand is dexterous and versatile, allowing it to interact with physical and virtual environments. The ability to track hand movements during daily activities could be of use in the development of spatial computing, virtual and augmented reality, robotics and prosthetics.
Tumour priming by ultrasound mechanogenetics for CAR T therapy - Nature Materials
Abstract Cell-based cancer immunotherapy holds potential as a therapeutic approach, yet its application for solid tumour treatment remains challenging. Here we report a focused-ultrasound-based approach that mechanically induces the localized expression of CD19 antigen within a subpopulation of cells within solid tumours, which function as local ‘training centres’ to activate chimeric antigen receptor T cells.
A programmable and self-adaptive ultrasonic wireless implant for personalized chronic pain management - Nature Electronics
Abstract Chronic pain management typically involves opioids, which are associated with severe side effects such as addiction. Implantable percutaneous electrical stimulators are a promising alternative approach to pain management. However, they are expensive, can cause damage during surgery and often rely on a battery power supply that must be periodically replaced.
Wearable flexible ultrasound microneedle patch for cancer immunotherapy - Nature Communications
Abstract Clinical approaches for cancer therapy face several interrelated challenges involving inefficient drug delivery, potential adverse side effects, and inconvenience. Here, we present an integrated wearable flexible ultrasound microneedle patch (wf-UMP) that serves as a portable platform for convenient, efficient, and minimally invasive cancer therapy.
Noninvasive imaging-guided ultrasonic neurostimulation with arbitrary 2D patterns and its application for high-quality vision restoration - Nature Communications
Abstract Retinal degeneration, a leading cause of irreversible low vision and blindness globally, can be partially addressed by retina prostheses which stimulate remaining neurons in the retina. However, existing electrode-based treatments are invasive, posing substantial risks to patients and healthcare providers. Here, we introduce a completely noninvasive ultrasonic retina prosthesis, featuring a customized ultrasound two-dimensional array which allows for simultaneous imaging and stimulation.
Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation - Nature Communications
Abstract Ultrasound-driven bioelectronics could offer a wireless scheme with sustainable power supply; however, current ultrasound implantable systems present critical challenges in biocompatibility and harvesting performance related to lead/lead-free piezoelectric materials and devices.
Growing recyclable and healable piezoelectric composites in 3D printed bioinspired structure for protective wearable sensor - Nature Communications
Abstract Bionic multifunctional structural materials that are lightweight, strong, and perceptible have shown great promise in sports, medicine, and aerospace applications. However, smart monitoring devices with integrated mechanical protection and piezoelectric induction are limited. Herein, we report a strategy to grow the recyclable and healable piezoelectric Rochelle salt crystals in 3D-printed cuttlebone-inspired structures to form a new composite for reinforcement smart monitoring devices.
Computational analysis of efficient organic solar cell-based retinal prosthesis using plasmonic gold nanoparticles
1. Introduction Age-related macular degeneration and retinitis pigmentosa are the most prevalent incurable eye diseases leading to photoreceptor degeneration and irreversible blindness (Wong et al., 2014). Age-related macular degeneration is the primary cause of irreversible vision loss in the elderly affecting 1.5% of Americans over 40 to >15% of those over 80, while retinitis pigmentosa affects younger people and leads to more vision loss (Palanker et al., 2022).
Non-Invasive Hybrid Ultrasound Stimulation of Visual Cortex In Vivo
4. Conclusions and Discussion In this experiment, we utilized US to target the VC and recorded the response of neuronal activities in the VC using electrophysiological and fiber-optic calcium signals in a rat model. Our results showed that the presence of the skull decreased the MI from 2.6 to 1.3~1.6 due to the thickness of the skull. This suggested that the ultrasound sound field could only partially penetrate the skull.
3D Printing and processing of miniaturized transducers with near-pristine piezoelectric ceramics for localized cavitation - Nature Communications
Fabrication of the 3D piezoelectric nanocomposites The fabrication process started with the preparation of the UV-sensitive piezocomposite colloid consisting of PZT 855 (APC Piezo, USA) particles, lead nitrate (MilliporeSigma, USA) and the UV-sensitive resin. The UV-sensitive resin was comprised of 1 wt% to 3 wt% photoinitiator Irg819 (MilliporeSigma, USA) and PEGDA (MilliporeSigma, USA).
Multilevel Structure Engineered Lead‐Free Piezoceramics Enabling Breakthrough in Energy Harvesting Performance for Bioelectronics
Abstract The prevalence of wearable/implantable medical electronics together with the rapid development of the Internet of Medicine Things call for the advancement of biocompatible, reliable, and high-efficiency energy harvesters. However, most current harvesters are based on toxic lead-based piezoelectric materials, raising biological safety concerns.
Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses - Nature Communications
Abstract Electronic visual prostheses, or biomimetic eyes, have shown the feasibility of restoring functional vision in the blind through electrical pulses to initiate neural responses artificially. However, existing visual prostheses predominantly use wired connections or electromagnetic waves for powering and data telemetry, which raises safety concerns or couples inefficiently to miniaturized implant units.
Noninvasive Ultrasound Retinal Stimulation for Vision Restoration at High Spatiotemporal Resolution
Objective. Retinal degeneration involving progressive deterioration and loss of function of photoreceptors is a major cause of permanent vision loss worldwide. Strategies to treat these incurable conditions incorporate retinal prostheses via electrically stimulating surviving retinal neurons with implanted devices in the eye, optogenetic therapy, and sonogenetic therapy. Existing challenges of these strategies include invasive manner, complex implantation surgeries, and risky gene therapy.
Photoacoustic and Piezo-Ultrasound Hybrid-Induced Energy Transfer for 3D Twining Wireless Multifunctional Implants
Photoacoustic and Piezo-Ultrasound Hybrid-Induced Energy Transfer for 3D Twining Wireless Multifunctional Implants Ultrasound-induced energy transfer (UET) represents an emerging technology that can be integrated into implantable medical systems for wirelessly powering and information communication. However, the spatial-temporal resolution, directivity, and versatility of the traditional piezo-ultrasound systems are generally limited.
Intravascular sensors to assess unstable plaques and their compositions: a review
Atherosclerosis and its thrombotic complications plague developed countries. The rupture of vulnerable atherosclerotic plaques contributes to acute cardiovascular events and sudden cardiac deaths.
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